Description

Fmoc-Nh-Peg4-Hz-Boc CAS NO 1263044-77-4 is a specialized heterobifunctional polyethylene glycol (PEG) crosslinker featuring orthogonal Fmoc and Boc protecting groups. This compound is engineered for precise, multi-step bioconjugation and peptide synthesis, offering controlled reactivity and solubility enhancement. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing antibody-drug conjugates (ADCs), peptide therapeutics, and diagnostic probes.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable, hydrophilic spacer to connect cytotoxic payloads to monoclonal antibodies, improving pharmacokinetics and therapeutic index.
• Peptide Synthesis & Modification: Used in solid-phase peptide synthesis (SPPS) to introduce PEGylated segments, hydrazone linkages, or functional handles for further derivatization.
• Bioconjugation & Protein Labeling: Facilitates the site-specific attachment of dyes, drugs, or other molecules to proteins, antibodies, or peptides via its hydrazine (Hz) and amine-reactive termini.
• Drug Delivery System Development: Incorporated into prodrugs and nanocarrier systems to enhance solubility, reduce immunogenicity, and enable controlled, pH-sensitive drug release.
• Diagnostic Reagent Formulation: Employed in the creation of contrast agents, imaging probes, and assay components where stable, water-soluble linkers are required.
• Biomaterial & Hydrogel Fabrication: Acts as a crosslinking agent or functional modifier in the synthesis of biocompatible polymers and hydrogels for tissue engineering and controlled release applications.

Basic Information

Product Name	Fmoc-Nh-Peg4-Hz-Boc
CAS No.	1263044-77-4
Molecular Formula	C37H55N3O11
Molecular Weight	717.85 g/mol
Synonyms	Fmoc-NH-PEG4-Hz-Boc; Fmoc-Amino-PEG4-Hydrazine-Boc; 9-Fluorenylmethyl N-[17-[(2-methyl-2-propanyl)oxy]-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaheptadec-1-yl]carbamate; Nα-Fmoc-Nω-Boc-8-amino-3,6-dioxaoctanoic acid hydrazide; Boc-Hydrazine-PEG4-Fmoc; Heterobifunctional PEG Crosslinker, Fmoc/Boc protected; Fmoc-N-amido-PEG4-Boc-hydrazide
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-Peg4-Hz-Boc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.