Description

Methyl 4-Phosphonobutanoate is a high-purity phosphonate ester building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals, agrochemicals, and functional materials, enabling the precise introduction of a phosphonate moiety. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new bioactive molecules or metal-chelating agents.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly those targeting bone diseases, enzyme inhibition, or acting as prodrugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, plant growth regulators, or fungicides with specific modes of action.
• Ligand and Chelator Precursor: Serves as a starting material for creating specialized phosphonate-based ligands used in catalysis, metal sequestration, or medical imaging agents.
• Material Science Research: Employed in the development of flame retardants, corrosion inhibitors, or surface-modifying agents for polymers and composites.
• Peptide Mimetics and Bioisosteres: Utilized in medicinal chemistry to replace carboxylic acid groups with phosphonate analogs, altering the pharmacokinetic properties of peptide-based therapeutics.
• Chemical Biology Probes: Acts as a synthetic handle for creating activity-based probes or inhibitors to study phosphonate-related biochemical pathways.

Basic Information

Product Name	Methyl 4-Phosphonobutanoate
CAS No.	1263034-23-6
Molecular Formula	C5H11O5P
Molecular Weight	182.11 g/mol
Synonyms	Methyl 4-phosphonobutyrate; 4-(Methoxyphosphinyl)butanoic acid methyl ester; Butanoic acid, 4-phosphono-, methyl ester; Phosphonobutyric acid methyl ester; Methyl phosphonobutylate; (4-Methoxy-4-oxobutyl)phosphonic acid; Dimethyl 4-phosphonobutanoate (common misnomer); POM-Butyrate Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Phosphonobutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.