Description

6-Fluoro-n-(4-Fluorobenzyl)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is valued for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research and development organizations and pharmaceutical manufacturers engaged in oncology and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel small-molecule drugs.
• Kinase Inhibitor Development: Serves as a core scaffold for creating potent and selective kinase inhibitors for cancer therapy.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate efficacy and safety profiles.
• Preclinical & Clinical Trial Material: Supplied as a high-grade intermediate for producing active pharmaceutical ingredients (APIs) for non-clinical and clinical studies.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production.

Basic Information

Product Name	6-Fluoro-n-(4-Fluorobenzyl)Quinazolin-4-Amine
CAS No.	1262888-28-7
Molecular Formula	C₁₆H₁₁F₂N₃
Molecular Weight	283.28 g/mol
Synonyms	4-Quinazolinamine, 6-fluoro-N-[(4-fluorophenyl)methyl]-; N-(4-Fluorobenzyl)-6-fluoroquinazolin-4-amine; 6-Fluoro-N-(4-fluorobenzyl)-4-quinazolinamine; 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine; 6-Fluoro-N-(4-fluorobenzyl)-4-aminoquinazoline; 1262888-28-7; 6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-ylamine
EINECS	Contact for details

Quality Control

Our 6-Fluoro-n-(4-Fluorobenzyl)Quinazolin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.