Description

5-(Trifluoromethyl)-[1,1'-Biphenyl]-3,4'-Dicarboxylic Acid is a high-value biphenyl derivative functionalized with a trifluoromethyl group and two carboxylic acid moieties, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its molecular architecture is engineered to introduce both lipophilicity and specific steric/electronic properties into target molecules, which is essential for developing compounds with enhanced metabolic stability and binding affinity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core component in the production of advanced electronic materials, including liquid crystals for displays and organic light-emitting diodes (OLEDs), due to its rigid biphenyl structure and tunable electronic properties.
• Metal-Organic Frameworks (MOFs): Acts as a functional organic linker in the construction of MOFs for gas storage, separation, and catalysis applications.
• Polymer Modification: Employed to introduce carboxylic acid functionality and fluorinated segments into polymers, enhancing their chemical resistance, adhesion properties, and surface characteristics.
• Cross-Coupling Reactions: A valuable substrate in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to create more complex biaryl systems for material science and drug discovery.

Basic Information

Product Name	5-(Trifluoromethyl)-[1,1'-Biphenyl]-3,4'-Dicarboxylic Acid
CAS No.	1261975-94-3
Molecular Formula	C15H9F3O4
Molecular Weight	310.23 g/mol
Synonyms	3,4'-Biphenyldicarboxylic Acid, 5-(Trifluoromethyl)-; [1,1'-Biphenyl]-3,4'-dicarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3,4'-biphenyldicarboxylic Acid; 5-Trifluoromethylbiphenyl-3,4'-dicarboxylic Acid; 3'-(Trifluoromethyl)-[1,1'-biphenyl]-4,5'-dicarboxylic acid (isomer); Biphenyl-3,4'-dicarboxylic acid derivative; TFM-BPDA
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-[1,1'-Biphenyl]-3,4'-Dicarboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay, NMR and IR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support compliance with REACH, FDA guidelines for drug intermediates, and can tailor quality standards to meet specific cGMP or customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is stable under inert atmosphere but should be kept away from strong acids and organic solvents as indicated by its chemical properties. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.