Description

3-(4-Boc-Aminophenyl)Picolinic Acid CAS NO 1261937-41-0 is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a picolinic acid moiety. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing novel active pharmaceutical ingredients (APIs) and bioconjugates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted therapeutics and investigational new drugs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a crucial linker component connecting E3 ligase ligands to target protein binders.
• Bioconjugation & ADC Development: Used in the creation of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of novel chemical entities.
• Peptidomimetic Synthesis: Incorporated into the design of peptide-like molecules with enhanced stability and bioavailability.
• Chemical Biology Probes: Acts as a foundational element for creating tools to study biological pathways and protein function.

Basic Information

Product Name	3-(4-Boc-Aminophenyl)Picolinic Acid
CAS No.	1261937-41-0
Molecular Formula	C17H18N2O4
Molecular Weight	314.34 g/mol
Synonyms	3-[4-[(tert-Butoxycarbonyl)amino]phenyl]pyridine-2-carboxylic Acid; 3-(4-(Boc-amino)phenyl)picolinic Acid; 2-Pyridinecarboxylic acid, 3-[4-[[(1,1-dimethylethoxy)carbonyl]amino]phenyl]-; tert-Butyl N-[4-(2-carboxypyridin-3-yl)phenyl]carbamate; Boc-PAPic-OH; 3-(4-(tert-Butoxycarbonylamino)phenyl)picolinic Acid
EINECS	Contact for details

Quality Control

Our 3-(4-Boc-Aminophenyl)Picolinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.