Description

3'-Chloro-5'-Fluoro-[1,1'-Biphenyl]-2-Carboxylic Acid is a high-purity biphenyl carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its unique halogenated aromatic structure, which is essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring halogenated biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides, where its structure can contribute to enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and liquid crystals, due to its rigid, conjugated biphenyl core.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.
• Academic and R&D Laboratories: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis for drug discovery.

Basic Information

Product Name	3'-Chloro-5'-Fluoro-[1,1'-Biphenyl]-2-Carboxylic Acid
CAS No.	1261915-22-3
Molecular Formula	C13H8ClFO2
Molecular Weight	250.65 g/mol
Synonyms	2-Biphenylcarboxylic acid, 3'-chloro-5'-fluoro-; 3'-Chloro-5'-fluorobiphenyl-2-carboxylic acid; [1,1'-Biphenyl]-2-carboxylic acid, 3'-chloro-5'-fluoro-; 2-(3-Chloro-5-fluorophenyl)benzoic acid; 3-Chloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid; 5-Fluoro-3'-chlorobiphenyl-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3'-Chloro-5'-Fluoro-[1,1'-Biphenyl]-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards, including cGMP intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.