Description

1-(Chloromethyl)-3-Methoxy-5-Nitrobenzene is a versatile aromatic building block characterized by its reactive chloromethyl and nitro functional groups. This compound is of significant value in organic synthesis, serving as a key intermediate for constructing more complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted benzylamine or benzyl alcohol motifs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where its nitro and chloromethyl groups allow for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of complex azo dyes and other colored compounds.
• Polymer Modification: Can be used to introduce functional groups into polymer chains for specialty materials with tailored properties.
• Cross-coupling Reactions: The aromatic chloride can participate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.

Basic Information

Product Name	1-(Chloromethyl)-3-Methoxy-5-Nitrobenzene
CAS No.	1261854-28-7
Molecular Formula	C8H8ClNO3
Molecular Weight	201.61 g/mol
Synonyms	3-Methoxy-5-nitrobenzyl chloride; 5-Nitro-3-methoxybenzyl chloride; 1-Chloromethyl-3-methoxy-5-nitrobenzene; (3-Methoxy-5-nitrophenyl)methyl chloride; α-Chloro-3-methoxy-5-nitrotoluene; NSC 406903; Benzene, 1-(chloromethyl)-3-methoxy-5-nitro-
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-3-Methoxy-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. Due to the reactive chloromethyl group, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.