Description

3-Chloro-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-value biphenyl carboxylic acid derivative, distinguished by its chloro and trifluoromethyl substituents which impart unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in therapeutic areas targeting inflammation, oncology, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a core structure or side-chain component in the synthesis of specialty materials for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating high-performance polymers with specific thermal and chemical resistance properties.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Coordination Chemistry: Can function as a ligand precursor for metal-organic frameworks (MOFs) or catalysts due to its carboxylic acid functionality.

Basic Information

Product Name	3-Chloro-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	1261822-09-6
Molecular Formula	C14H8ClF3O2
Molecular Weight	300.66 g/mol
Synonyms	[1,1'-Biphenyl]-4-carboxylic acid, 3-chloro-4'-(trifluoromethyl)-; 3-Chloro-4'-(trifluoromethyl)biphenyl-4-carboxylic acid; 4'-Trifluoromethyl-3-chlorobiphenyl-4-carboxylic acid; 3-Chloro-4'-(trifluoromethyl)-1,1'-biphenyl-4-carboxylic acid; Biphenyl-4-carboxylic acid, 3-chloro-4'-(trifluoromethyl)-; CAS 1261822-09-6
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-4'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis steps. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards, and specifications can be tailored to meet the rigorous demands of pharmaceutical (ICH Q3A/B) and agrochemical regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.