Description

3-Hydroxy-5-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block characterized by its quinoline core substituted with a hydroxyl group and a trifluoromethyl moiety. This unique structure makes it a critical intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), particularly where enhanced lipophilicity and metabolic stability are required. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Research: Used in the synthesis of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Synthesis: Employed in organic chemistry research for constructing complex heterocyclic systems via cross-coupling and functional group transformations.
• Ligand & Catalyst Development: Utilized to create novel chelating ligands for metal catalysis in asymmetric synthesis.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the influence of the trifluoromethyl group on chemical reactivity and physical properties.

Basic Information

Product Name	3-Hydroxy-5-(Trifluoromethyl)Quinoline
CAS No.	1261678-80-1
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	5-(Trifluoromethyl)quinolin-3-ol; 3-Hydroxy-5-trifluoromethylquinoline; 5-Trifluoromethyl-3-quinolinol; Quinoline, 3-hydroxy-5-(trifluoromethyl)-; 3-Quinolinol, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy-5-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.