Description

Phenol, 3-Amino-5-(Trifluoromethoxy)- is a specialized fluorinated aniline derivative, serving as a high-value building block in advanced organic synthesis. Its molecular structure, featuring both an amino group and a trifluoromethoxy substituent on a phenolic core, makes it a critical intermediate for creating compounds with enhanced biological activity and physicochemical properties. This chemical is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorine motifs for improved metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance pesticidal activity and environmental stability.
• Material Science Research: Building block for advanced polymers, liquid crystals, and organic electronic materials requiring specific fluorine-based functionalization.
• Dye and Pigment Chemistry: Intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library development in drug discovery programs.

Basic Information

Product Name	Phenol, 3-Amino-5-(Trifluoromethoxy)-
CAS No.	1261650-51-4
Molecular Formula	C7H6F3NO2
Molecular Weight	193.12 g/mol
Synonyms	3-Amino-5-(trifluoromethoxy)phenol; 5-Amino-3-(trifluoromethoxy)phenol; 3-Hydroxy-5-(trifluoromethoxy)aniline; 5-(Trifluoromethoxy)-3-aminophenol; 1-Amino-3-hydroxy-5-(trifluoromethoxy)benzene; Benzene, 1-amino-3-hydroxy-5-(trifluoromethoxy)-; (3-Amino-5-hydroxyphenyl) trifluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of Phenol, 3-Amino-5-(Trifluoromethoxy)- is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.