Description

4-[(3-Trifluoromethyl)Phenyl]-Pyridine-2-Carboxylic Acid CAS NO 1261637-33-5 is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine-carboxylic acid core and trifluoromethylphenyl substituent. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers seeking to incorporate this specific fluorinated aromatic scaffold into their molecular designs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the trifluoromethyl and pyridine motifs.
• Ligand Synthesis: Serves as a precursor for creating complex ligands in catalysis and material science applications.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Fluorinated Compound Libraries: An essential component for combinatorial chemistry and the creation of diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	4-[(3-Trifluoromethyl)Phenyl]-Pyridine-2-Carboxylic Acid
CAS No.	1261637-33-5
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	2-Pyridinecarboxylic acid, 4-[3-(trifluoromethyl)phenyl]-; 4-(3-(Trifluoromethyl)phenyl)picolinic acid; 4-(3-Trifluoromethylphenyl)picolinic acid; 4-(α,α,α-Trifluoro-m-tolyl)picolinic acid; 4-(m-Trifluoromethylphenyl)-2-pyridinecarboxylic acid; 1261637-33-5
EINECS	Contact for details

Quality Control

Every batch of 4-[(3-Trifluoromethyl)Phenyl]-Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.