Description

5-Fluoro-3-(3-Trifluoromethoxyphenyl)Benzoic Acid is a high-purity, multi-functional aromatic carboxylic acid building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for developing novel compounds with tailored properties. This product is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a sophisticated monomer for synthesizing advanced organic electronic materials used in displays and lighting technologies.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent for creating specialty polymers with specific thermal, chemical, or surface properties.
• Chemical Research & Development: A versatile scaffold in medicinal and synthetic chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorinated Compound Library Synthesis: Essential for constructing diverse libraries of fluorinated compounds for high-throughput screening in various life science applications.

Basic Information

Product Name	5-Fluoro-3-(3-Trifluoromethoxyphenyl)Benzoic Acid
CAS No.	1261460-04-1
Molecular Formula	C14H8F4O3
Molecular Weight	300.21 g/mol
Synonyms	3'-Trifluoromethoxy-5-fluorobiphenyl-3-carboxylic Acid; 5-Fluoro-3'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic Acid; [1,1'-Biphenyl]-3-carboxylic acid, 5-fluoro-3'-(trifluoromethoxy)-; 5-Fluoro-3-(3-(trifluoromethoxy)phenyl)benzoic Acid; 3-(3-(Trifluoromethoxy)phenyl)-5-fluorobenzoic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards and customer-specific requirements. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available for every batch, providing full transparency on specifications. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.