Description

3-Bromo-5-(Difluoromethoxy)Anisole is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and alkoxy-substituted aromatic structure. This compound matters as a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), enabling precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the difluoromethoxy and bromo groups contribute to bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and material science applications.
• Organic Electronic Materials: Employed in the synthesis of functionalized aromatic compounds for organic light-emitting diodes (OLEDs) and semiconductors.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom chemical synthesis services catering to specific client R&D projects.
• Life Science Research: Utilized in biochemical research as a probe or labeling agent due to its reactive bromine moiety.

Basic Information

Product Name	3-Bromo-5-(Difluoromethoxy)Anisole
CAS No.	1261446-31-4
Molecular Formula	C8H7BrF2O2
Molecular Weight	253.04 g/mol
Synonyms	1-Bromo-3-(difluoromethoxy)-5-methoxybenzene; Benzene, 1-bromo-3-(difluoromethoxy)-5-methoxy-; 3-Bromo-5-(difluoromethoxy)methoxybenzene; 5-Bromo-3-(difluoromethoxy)anisole; Anisole, 3-bromo-5-(difluoromethoxy)-; 3-(Difluoromethoxy)-5-methoxybromobenzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Difluoromethoxy)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.5%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.