Description

3-(Trifluoromethyl)-1,8-Naphthyridine CAS NO 1261365-77-8 is a high-value, fluorinated heterocyclic compound belonging to the naphthyridine class, characterized by the presence of a trifluoromethyl group which imparts unique physicochemical properties. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for the creation of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used as a building block for synthesizing novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Employed in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient naphthyridine core.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel chelating ligands in coordination chemistry and catalysis.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in heterocyclic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.

Basic Information

Product Name	3-(Trifluoromethyl)-1,8-Naphthyridine
CAS No.	1261365-77-8
Molecular Formula	C9H5F3N2
Molecular Weight	198.15 g/mol
Synonyms	3-(Trifluoromethyl)-1,8-naphthyridine; 1,8-Naphthyridine, 3-(trifluoromethyl)-; 3-Trifluoromethyl-1,8-naphthyridine; 3-(Trifluoromethyl)-1,8-naphthyridin; 1261365-77-8
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-1,8-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.