Description

5-(Trifluoromethyl)-4-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its molecular architecture, featuring a pyrrolopyridine core, a trifluoromethyl group, and a protected ethynyl handle, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key structural motifs that can modulate bioactivity, metabolic stability, and physicochemical characteristics. The CAS number for this compound is 1261365-60-9.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrrolopyridine scaffold.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of advanced organic electronic materials and polymers.
• Chemical Biology Probe Development: Employed to create tagged or labeled compounds for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne group is a versatile handle for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry: The trifluoromethyl group is a valuable pharmacophore, making this compound ideal for medicinal chemistry programs focused on improving potency and membrane permeability.

Basic Information

Product Name	5-(Trifluoromethyl)-4-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1261365-60-9
Molecular Formula	C13H13F3N2Si
Molecular Weight	282.34 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-(trifluoromethyl)-4-[(trimethylsilyl)ethynyl]-; 5-Trifluoromethyl-4-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine; TMS-Ethynyl Pyrrolopyridine Trifluoromethyl Derivative; Pyrrolopyridine TMS Alkyne Building Block
EINECS	Contact for details

Quality Control

Every batch of 5-(Trifluoromethyl)-4-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure compliance with exacting purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.