Description

2-(4-Cyanophenyl)-2,2-Difluoroacetic Acid is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both a cyano group and a difluoroacetic acid moiety, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of monomers and polymers for advanced materials, such as liquid crystals or specialty polymers with tailored properties.
• Fluorine Chemistry Research: An important compound for academic and industrial research focused on incorporating fluorine atoms into complex organic architectures to study structure-activity relationships.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(4-Cyanophenyl)-2,2-Difluoroacetic Acid
CAS No.	1261358-84-2
Molecular Formula	C9H5F2NO2
Molecular Weight	197.14 g/mol
Synonyms	4-Cyano-α,α-difluorophenylacetic Acid; 2,2-Difluoro-2-(4-cyanophenyl)acetic Acid; (4-Cyanophenyl)difluoroacetic Acid; α,α-Difluoro-4-cyanobenzeneacetic Acid; 2-(4-Cyanophenyl)-2,2-difluoroethanoic Acid; p-Cyanophenyl(difluoro)acetic Acid; Difluoro(4-cyanophenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Standard quality control includes identification by spectroscopic methods (NMR, IR), purity determination by HPLC, and control of specific impurities. Certificates of Analysis (COA) documenting all test results are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate engineering controls.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.