Description

(R)-3-(3,4-Dichloro-Benzyloxy)-Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial and research interest. Its defined stereochemistry and functionalized pyrrolidine core make it a critical precursor for the synthesis of advanced active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Asymmetric Synthesis: Used as a building block for constructing complex molecules with defined stereocenters in medicinal chemistry and process chemistry.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the synthesis of advanced, biologically active compounds for crop protection and pest management.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Scale-Up: Supplied for pilot plant and commercial-scale manufacturing of target APIs requiring this specific chiral motif.

Basic Information

Product Name	(R)-3-(3,4-Dichloro-Benzyloxy)-Pyrrolidine Hydrochloride
CAS No.	1261234-83-6
Molecular Formula	C11H13Cl2NO • HCl
Molecular Weight	282.59 g/mol (Free base: 246.13 g/mol)
Synonyms	(R)-3-[(3,4-Dichlorophenyl)methoxy]pyrrolidine hydrochloride; (R)-3-(3,4-Dichlorobenzyloxy)pyrrolidine HCl; (R)-N-Boc-3-(3,4-dichlorobenzyloxy)pyrrolidine (precursor); Pyrrolidine, 3-[(3,4-dichlorophenyl)methoxy]-, hydrochloride, (3R)-; (3R)-3-[(3,4-Dichlorobenzyl)oxy]pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(3,4-Dichloro-Benzyloxy)-Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.