Description

1-[(3-Fluorophenyl)Methyl]-1H-1,2,3-Triazole-4-Carboxylic Acid is a high-value fluorinated triazole derivative, a key synthetic intermediate prized for its unique molecular architecture. This compound matters for its role in constructing complex molecules, particularly in advanced pharmaceutical research and agrochemical development. It is primarily needed by R&D chemists and process development scientists in the life sciences sector, where it serves as a critical building block for new active ingredients.

Application

• Pharmaceutical Intermediate: A versatile building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of new generation pesticides and herbicides, where the fluorinated triazole moiety can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and materials science, useful in asymmetric synthesis and metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Employed in the design of activity-based probes and molecular tags for studying enzyme function and protein interactions.
• Peptidomimetics & Bioisosteres: The carboxylic acid functionality allows for coupling to create triazole-containing peptidomimetics, used to improve the metabolic stability of peptide-based therapeutics.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in heterocyclic chemistry and fluorine chemistry research.

Basic Information

Product Name	1-[(3-Fluorophenyl)Methyl]-1H-1,2,3-Triazole-4-Carboxylic Acid
CAS No.	1260912-27-3
Molecular Formula	C10H8FN3O2
Molecular Weight	221.19 g/mol
Synonyms	1-[(3-Fluorobenzyl)]-1H-1,2,3-triazole-4-carboxylic acid; 4-Carboxy-1-(3-fluorobenzyl)-1,2,3-triazole; 1-(3-Fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid; 1H-1,2,3-Triazole-4-carboxylic acid, 1-[(3-fluorophenyl)methyl]-; 3-Fluorobenzyl-1H-1,2,3-triazole-4-carboxylic acid; (1-(3-Fluorobenzyl)-1H-1,2,3-triazol-4-yl)methanoic acid; FBTZ-COOH; 1260912-27-3 (CAS Name)
EINECS	Contact for details

Quality Control

Our 1-[(3-Fluorophenyl)Methyl]-1H-1,2,3-Triazole-4-Carboxylic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.