Description

(R)-2-(5-Fluoro-2-Methoxyphenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, which are critical for the synthesis of advanced active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries, particularly those focused on central nervous system (CNS) and neurological disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, especially those targeting neurological pathways.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective chemical reactions to create enantiomerically pure compounds.
• Medicinal Chemistry R&D: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Employed as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Process Chemistry: Utilized in the development and scale-up of efficient, GMP-compliant manufacturing routes for complex APIs.

Basic Information

Product Name	(R)-2-(5-Fluoro-2-Methoxyphenyl)Pyrrolidine Hydrochloride
CAS No.	1260845-67-7
Molecular Formula	C11H15ClFNO
Molecular Weight	231.70 g/mol
Synonyms	(R)-5-Fluoro-2-methoxy-α-(2-pyrrolidinyl)benzene hydrochloride; (R)-2-(5-Fluoro-2-methoxyphenyl)pyrrolidine HCl; (R)-5-Fluoro-2-methoxyamphetamine pyrrolidine hydrochloride (contextual); (R)-FMPP HCl; (R)-2-(5-Fluoro-2-methoxyphenyl)-1-azacyclopentane hydrochloride; (R)-1-(5-Fluoro-2-methoxyphenyl)-2-pyrrolidinylmethane hydrochloride; (R)-2-(5-Fluoro-2-methoxyphenyl)pyrrolidine, hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(5-Fluoro-2-Methoxyphenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing full specifications, including enantiomeric excess (ee), is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.