Description

tert-Butyl 5-Nitrospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of critical importance for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and process development of new therapeutic agents, especially within central nervous system (CNS) and oncology drug pipelines.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential drug candidates, particularly those with spirocyclic or fused heterocyclic structures.
• Medicinal Chemistry Research: Used extensively in research laboratories for structure-activity relationship (SAR) studies and the construction of compound libraries for high-throughput screening.
• API (Active Pharmaceutical Ingredient) Development: Employed in the process development and scale-up stages for new chemical entities (NCEs), especially in neurological and oncological therapeutic areas.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Chemical Biology Probes: Utilized in the development of specialized chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 5-Nitrospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1260843-22-8
Molecular Formula	C17H23N3O4
Molecular Weight	333.38 g/mol
Synonyms	1'-Boc-5-Nitrospiro[indoline-3,4'-piperidine]; 5-Nitro-1'-Boc-spiro[indoline-3,4'-piperidine]; tert-Butyl 5-nitro-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 5-Nitrospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,2-Dihydro-5-nitrospiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; Boc-5-Nitrospiro[indoline-3,4'-piperidine]; 1260843-22-8; 5-Nitro-1'-Boc-spiro[indoline-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Nitrospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Conforms to ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.