Description

3-Amino-1,1,1-Trifluoropropan-2-One Hydrochloride is a high-purity, non-racemic trifluoromethyl ketone derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the unique reactivity of the amino ketone hydrochloride group combined with the electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl moiety. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of bioactive molecules, including protease inhibitors, kinase inhibitors, and other targeted therapeutics.
• Agrochemical Research: Used in constructing advanced intermediates for novel herbicides, fungicides, and insecticides that leverage fluorine chemistry for improved efficacy and environmental profile.
• Fluorine Chemistry & Material Science: Serves as a precursor for introducing the CF3 group into more complex organic frameworks for specialty polymers, liquid crystals, or electronic materials.
• Asymmetric Synthesis: Employed as a substrate or reagent in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Chemical Biology & Proteomics: Can be utilized in the design and synthesis of activity-based probes (ABPs) or affinity labels for studying enzyme function.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high-purity, complex fluorinated building blocks.

Basic Information

Product Name	3-Amino-1,1,1-Trifluoropropan-2-One Hydrochloride
CAS No.	1260812-54-1
Molecular Formula	C3H5ClF3NO
Molecular Weight	163.52 g/mol
Synonyms	1,1,1-Trifluoro-3-amino-2-propanone hydrochloride; 3-Amino-1,1,1-trifluoroacetone hydrochloride; 3-Amino-1,1,1-trifluoropropan-2-one HCl; 3-Amino-1,1,1-trifluoro-2-propanone hydrochloride; 1,1,1-Trifluoro-3-aminopropan-2-one hydrochloride; 3-Amino-1,1,1-trifluoroacetone HCl salt; (Aminotrifluoroacetone) hydrochloride; ATFA hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-1,1,1-Trifluoropropan-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.