Description

4-Methoxy-2-Trifluoromethoxynitrobenzene is a high-value, multi-functional aromatic intermediate featuring both methoxy and trifluoromethoxy substituents on a nitrobenzene core. This compound is strategically important for its role in synthesizing advanced pharmaceutical and agrochemical molecules, where its unique fluorine-containing moiety can significantly enhance biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group contributes to improved lipophilicity and pest control efficacy.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro and fluorine-containing groups.
• Dye and Pigment Intermediate: Employed in the production of specialized dyes and pigments where the substituents modify color properties and lightfastness.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	4-Methoxy-2-Trifluoromethoxynitrobenzene
CAS No.	1260770-16-8
Molecular Formula	C9H6F3NO4
Molecular Weight	249.14 g/mol
Synonyms	1-Methoxy-4-nitro-2-(trifluoromethoxy)benzene; 2-Nitro-4-methoxy-1-(trifluoromethoxy)benzene; 4-Methoxy-2-(trifluoromethoxy)nitrobenzene; 4-Methoxy-α,α,α-trifluoro-2-nitrophenyl methyl ether; Benzene, 1-methoxy-4-nitro-2-(trifluoromethoxy)-; 2-(Trifluoromethoxy)-4-methoxynitrobenzene
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2-Trifluoromethoxynitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.