Description

2-(Trifluoromethyl)Quinoline-5-Carboxylic Acid is a high-value, multifunctional heterocyclic building block characterized by its quinoline core and trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the CF3 group is prized for its ability to modulate lipophilicity, metabolic stability, and binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging the biological activity of the quinoline scaffold.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, fluorescent dyes, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for developing molecular probes and tags due to its derivatizable carboxylic acid group.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(Trifluoromethyl)Quinoline-5-Carboxylic Acid
CAS No.	1260671-21-3
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	5-Quinolinecarboxylic acid, 2-(trifluoromethyl)-; 2-Trifluoromethylquinoline-5-carboxylic acid; Quinoline-5-carboxylic acid, 2-(trifluoromethyl)-; 1260671-21-3; 2-(Trifluoromethyl)-5-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Quinoline-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.