Description

4-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine is a brominated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drug candidates, particularly in kinase inhibitor programs and central nervous system (CNS) targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for lead optimization and identification.
• Agrochemical Synthesis: Serves as a precursor in the design and synthesis of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Employed in the synthesis of novel chelating ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: A building block for creating organic electronic materials and photoactive compounds.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	4-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine
CAS No.	1260670-12-9
Molecular Formula	C8H9BrN2
Molecular Weight	213.08 g/mol
Synonyms	4-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine; 5,6,7,8-Tetrahydro-4-bromo-1,6-naphthyridine; 4-Bromo-1,6-naphthyridine, 5,6,7,8-tetrahydro-; 4-Bromo-5,6,7,8-tetrahydro[1,6]naphthyridine; 1260670-12-9; 4-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridin; Tetrahydro-4-bromo-1,6-naphthyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption. Recommended storage temperature is 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.