Description

trans-(3-Fluorocyclobutyl)Methamine Hydrochloride is a high-purity fluorinated cyclobutylamine derivative, offered as a stable hydrochloride salt for advanced chemical synthesis. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the introduction of a constrained, fluorine-substituted cyclobutyl scaffold. It is primarily utilized by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to modulate the physicochemical and metabolic properties of new molecular entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery.
• Medicinal Chemistry Research: Used to explore structure-activity relationships (SAR) by incorporating a rigid, fluorinated cyclobutane ring to influence potency, selectivity, and metabolic stability.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and biological pathways.
• Peptidomimetics: Incorporation into peptide analogs to enhance conformational rigidity and bioavailability.

Basic Information

Product Name	trans-(3-Fluorocyclobutyl)Methamine Hydrochloride
CAS No.	1260664-80-9
Molecular Formula	C6H13ClFN
Molecular Weight	153.63 g/mol
Synonyms	trans-1-(Aminomethyl)-3-fluorocyclobutane hydrochloride; (1R,3S)- and (1S,3R)-1-(Aminomethyl)-3-fluorocyclobutane hydrochloride; 3-Fluorocyclobutanemethanamine hydrochloride, trans-; trans-3-Fluorocyclobutanemethylamine HCl; (trans)-3-Fluorocyclobutylmethylamine hydrochloride; FCBMA-HCl; 1260664-80-9
EINECS	Contact for details

Quality Control

Our trans-(3-Fluorocyclobutyl)Methamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
trans-Isomer Content (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.