Description

2,3-Difluoro-L-Homophenylalanine is a non-natural, fluorinated amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a critical building block in the design of novel peptide-based therapeutics and bioactive molecules, where the strategic fluorine substitution can dramatically alter metabolic stability, lipophilicity, and receptor binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for applications in drug discovery and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide drugs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorine atoms on pharmacokinetic properties.
• Peptide Modification: Incorporated into peptide sequences to enhance metabolic stability and membrane permeability.
• Agrochemical Development: Serves as a precursor for novel fluorinated active ingredients with improved efficacy.
• Biochemical Tool: Utilized in the study of enzyme mechanisms and as a substrate analog for fluorinated enzyme assays.
• Ligand Synthesis: Building block for creating specialized ligands used in asymmetric catalysis and molecular recognition.

Basic Information

Product Name	2,3-Difluoro-L-Homophenylalanine
CAS No.	1260616-60-1
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	(S)-2-Amino-4-(2,3-difluorophenyl)butanoic acid; L-2,3-Difluorohomophenylalanine; H-2,3-Difluoro-hPhe-OH; 2,3-Difluoro-DL-homophenylalanine (racemic mixture); 4-(2,3-Difluorophenyl)-L-homoalanine; (2S)-2-Amino-4-(2,3-difluorophenyl)butanoic acid; Fluorinated phenylalanine derivative
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-L-Homophenylalanine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥97% by HPLC), and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.