Description

(R)-2-tert-Butoxycarbonylamino-4-(3-Fluoro-Phenyl)-Butyric Acid CAS NO 1260615-14-2 is a high-purity, non-natural amino acid derivative featuring a chiral center and a fluorinated aromatic side chain. This compound is a critical pharmaceutical intermediate used in the synthesis of complex bioactive molecules, particularly peptidomimetics and enzyme inhibitors. It is essential for research and development in medicinal chemistry and large-scale production within the fine chemical and pharmaceutical industries.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of Active Pharmaceutical Ingredients (APIs), especially those targeting neurological and oncological pathways.
• Peptidomimetic Drug Development: Used to incorporate fluorinated phenylalanine analogs into peptide chains to enhance metabolic stability, bioavailability, and binding affinity.
• Protease Inhibitor Research: A valuable scaffold in the design and synthesis of inhibitors for various proteases, including renin and HIV protease.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and as a starting material for generating other enantiomerically pure compounds due to its defined (R)-configuration.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Services: Supplied to CDMOs (Contract Development and Manufacturing Organizations) and research institutions for custom peptide synthesis projects.

Basic Information

Product Name	(R)-2-tert-Butoxycarbonylamino-4-(3-Fluoro-Phenyl)-Butyric Acid
CAS No.	1260615-14-2
Molecular Formula	C15H20FNO4
Molecular Weight	297.32 g/mol
Synonyms	(R)-Boc-3-F-Phe-OH; (R)-N-Boc-3-Fluorophenylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid; (R)-N-(tert-Butoxycarbonyl)-3-fluorophenylalanine; Boc-(R)-3-F-Phe-OH; (R)-Boc-3-Fluoro-L-homophenylalanine; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-4-(3-fluorophenyl)butanoic acid; (3-Fluorophenyl)-D-homoalanine N-Boc derivative
EINECS	Contact for details

Quality Control

Our (R)-2-tert-Butoxycarbonylamino-4-(3-Fluoro-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled and stored away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.