Description

(R)-4-(4-Bromo-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a bromophenyl side chain, protected by the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the precise introduction of structural and functional diversity. It is primarily utilized by researchers and manufacturers in pharmaceutical R&D for developing novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: In the research and development of novel drug candidates, particularly those targeting protein-protein interactions.
• Peptidomimetic Design: For creating stable, bioavailable analogs of natural peptides with enhanced pharmacological properties.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying biological pathways and mechanisms.
• API (Active Pharmaceutical Ingredient) Development: As a key chiral intermediate in the synthetic route of complex target molecules.
• Academic & Industrial Research: For exploring structure-activity relationships (SAR) in medicinal chemistry programs.

Basic Information

Item	Details
Product Name	(R)-4-(4-Bromo-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid
CAS No.	1260615-07-3
Molecular Formula	C25H22BrNO4
Molecular Weight	480.35 g/mol
Synonyms	Fmoc-(R)-4-(4-Bromo-Phenyl)-2-Aminobutyric Acid; (R)-Fmoc-4-(4-Bromophenyl)homoalanine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(4-bromophenyl)butanoic acid; Fmoc-4-(4-Br-Ph)-hAla-OH (R); (R)-4-(4-Bromophenyl)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid; (R)-N-Fmoc-4-(4-bromophenyl)homophenylalanine; Fmoc-(R)-4-(p-Bromophenyl)-2-aminobutanoic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed to confirm identity, purity, and chiral integrity, meeting the stringent requirements for pharmaceutical research applications. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.