Description

(S)-4-Biphenyl-3-Yl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid is a sophisticated chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its core value lies in enabling the precise construction of complex peptide-based molecules and pharmaceutical intermediates with defined stereochemistry. This compound is essential for researchers and manufacturers in pharmaceutical development, peptide chemistry, and advanced material science, where high-purity, structurally defined intermediates are critical for successful outcomes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative, where the Fmoc (9-fluorenylmethoxycarbonyl) group offers orthogonal protection strategies.
• Chemical Biology Research: Employed in the design and synthesis of peptide probes, inhibitors, and labeled compounds for studying biological mechanisms and protein interactions.
• Asymmetric Synthesis: Serves as a chiral starting material or auxiliary for constructing complex molecules with high enantiomeric purity in medicinal chemistry campaigns.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-4-Biphenyl-3-Yl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid
CAS No.	1260594-85-1
Molecular Formula	C31H27NO4
Molecular Weight	477.55 g/mol
Synonyms	Fmoc-(S)-4-Biphenyl-3-yl-Alanine-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-([1,1'-biphenyl]-3-yl)propanoic acid; Fmoc-3-(3-Biphenylyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-biphenylyl)-L-alanine; (S)-2-(Fmoc-amino)-3-(biphenyl-3-yl)propanoic acid; Fmoc-L-3-Biphenylalanine; Biphenyl-3-yl-L-alanine Fmoc derivative
EINECS	Contact for details

Quality Control

Our production of (S)-4-Biphenyl-3-Yl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.