Description

(2R)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[2-(Trifluoromethoxy)Phenyl]Butanoic Acid is a sophisticated, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical Fmoc-protected building block for the solid-phase synthesis of complex peptides, enabling the precise incorporation of a unique trifluoromethoxy-phenyl side chain. It is essential for medicinal chemists and process development scientists working on novel therapeutics, particularly in the areas of targeted drug discovery and peptidomimetic design.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides containing the 2-(trifluoromethoxy)phenylalanine residue.
• Medicinal Chemistry & Drug Discovery: Used to create peptide libraries and novel lead compounds for screening against various biological targets, leveraging the unique physicochemical properties of the trifluoromethoxy group.
• Peptidomimetic Development: Facilitates the design and synthesis of peptide-like molecules with enhanced metabolic stability, bioavailability, and receptor binding affinity.
• Pharmaceutical Intermediate: Serves as a high-purity intermediate in the research-scale production of potential active pharmaceutical ingredients (APIs) and diagnostic agents.
• Bioconjugation & Probe Synthesis: Can be utilized in the construction of labeled peptides for biochemical assays, imaging studies, and targeted delivery systems.

Basic Information

Product Name	(2R)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[2-(Trifluoromethoxy)Phenyl]Butanoic Acid
CAS No.	1260594-46-4
Molecular Formula	C26H22F3NO5
Molecular Weight	485.45 g/mol
Synonyms	Fmoc-(R)-2-(Trifluoromethoxy)phenylalanine; Fmoc-O-CF3-Phe-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethoxy)phenyl)propanoic Acid; Fmoc-2-(Trifluoromethoxy)-D-phenylalanine; Fmoc-D-2-O-CF3-Phe; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(trifluoromethoxy)-D-phenylalanine; Nα-Fmoc-2-(trifluoromethoxy)-D-phenylalanine; Fmoc-D-TfmPhe-OH
EINECS	Contact for details

Quality Control

Our (2R)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[2-(Trifluoromethoxy)Phenyl]Butanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and NMR confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming identity, purity, and compliance with in-house specifications designed for pharmaceutical R&D use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.