Description

(S)-A-(Boc-Amino)-3,5-Difluorobenzenebutanoic Acid CAS NO 1260592-43-5 is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a carboxylic acid functional group on a difluorinated benzene scaffold. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Research: Used to incorporate fluorinated, non-natural amino acid residues into peptide backbones to enhance metabolic stability and binding affinity.
• API Development: Serves as a building block in the research and scale-up production of candidate drug molecules, particularly those targeting central nervous system (CNS) disorders and oncology.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a chiral starting material or auxiliary in stereoselective chemical transformations.

Basic Information

Product Name	(S)-A-(Boc-Amino)-3,5-Difluorobenzenebutanoic Acid
CAS No.	1260592-43-5
Molecular Formula	C15H19F2NO4
Molecular Weight	315.32 g/mol
Synonyms	(S)-4-((tert-Butoxycarbonyl)amino)-3,5-difluorobenzenebutanoic Acid; (S)-3-(3,5-Difluoro-4-((((2-methyl-2-propanyl)oxy)carbonyl)amino)phenyl)propanoic Acid; (S)-Boc-3,5-Difluoro-DL-phenylalanine derivative; Boc-(S)-A-(Amino)-3,5-Difluorohydrocinnamic Acid; (S)-Boc-AADF; tert-Butyl (S)-(3,5-difluoro-4-(3-carboxypropyl)phenyl)carbamate
EINECS	Contact for details

Quality Control

Our (S)-A-(Boc-Amino)-3,5-Difluorobenzenebutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.