Description

6-Chloro-5-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-One is a high-purity fluorinated and chlorinated tetralone derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its unique halogenated bicyclic structure, which is essential for constructing complex molecules in modern medicinal chemistry. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological and cardiovascular diseases.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex polycyclic frameworks and studying halogenation effects on molecular properties.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation herbicides and pesticides with enhanced activity.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials due to its halogenated aromatic system.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	6-Chloro-5-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-One
CAS No.	1260013-97-5
Molecular Formula	C₁₀H₈ClFO
Molecular Weight	198.62 g/mol
Synonyms	6-Chloro-5-fluoro-3,4-dihydro-1(2H)-naphthalenone; 6-Chloro-5-fluoro-1-tetralone; 6-Chloro-5-fluoro-3,4-dihydronaphthalen-1(2H)-one; 1(2H)-Naphthalenone, 6-chloro-5-fluoro-3,4-dihydro-; 6-Chloro-5-fluoro-α-tetralone; 6-Chloro-5-fluoro-1-oxo-1,2,3,4-tetrahydronaphthalene
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.