Description

2,4,5-Trifluoro-Dl-Phenylalanine is a fluorinated derivative of the essential amino acid phenylalanine, serving as a critical chiral building block in advanced organic synthesis. This compound matters for its unique trifluoromethyl substitution pattern, which imparts enhanced metabolic stability and lipophilicity to target molecules, a key requirement in modern drug discovery. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in oncology and CNS disorders.
• Agrochemical Synthesis: Used in creating advanced, high-performance herbicides and pesticides with improved environmental profiles.
• Peptide Chemistry: Incorporation into custom peptides to study structure-activity relationships (SAR) and enhance peptide stability.
• Proteomics & Biochemical Research: Serves as a tool compound in metabolic pathway studies and enzyme inhibition assays.
• Material Science: Potential monomer or additive for developing specialty polymers with unique surface properties.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects requiring fluorinated amino acid analogs.

Basic Information

Product Name	2,4,5-Trifluoro-Dl-Phenylalanine
CAS No.	1260002-73-0
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	DL-2,4,5-Trifluorophenylalanine; (RS)-2-Amino-3-(2,4,5-trifluorophenyl)propanoic acid; 2,4,5-Trifluoro-DL-phenylalanine; 2,4,5-Trifluorophenylalanine, DL-; 3-(2,4,5-Trifluorophenyl)-DL-alanine; (±)-2-Amino-3-(2,4,5-trifluorophenyl)propionic acid; NSC 87680; Amino acid TFPA
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluoro-Dl-Phenylalanine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.