Description

3-Chloro-2-Fluoro-Dl-Phenylalanine is a halogenated derivative of the essential amino acid phenylalanine, serving as a sophisticated chiral building block in advanced organic synthesis. This compound matters for its unique structural features, which allow for the precise introduction of chlorine and fluorine atoms into complex molecular architectures, enabling fine-tuning of biological activity and physicochemical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in protease inhibitor and CNS-active compound libraries.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides where halogenated amino acid motifs can enhance stability and binding affinity.
• Peptide Chemistry: Incorporation into custom peptides to study structure-activity relationships (SAR) and modulate peptide stability, lipophilicity, and receptor interaction.
• Chemical Biology Probe Development: Serves as a building block for creating activity-based probes (ABPs) or labeled compounds to study enzyme function and metabolic pathways.
• Material Science: Potential monomer or precursor for specialized polymers and coatings where halogenated aromatic groups impart specific material properties.
• Academic & Contract Research: A valuable reagent for methodological studies in asymmetric synthesis, fluorination chemistry, and medicinal chemistry programs.

Basic Information

Product Name	3-Chloro-2-Fluoro-Dl-Phenylalanine
CAS No.	1259993-84-4
Molecular Formula	C9H9ClFNO2
Molecular Weight	217.62 g/mol
Synonyms	DL-3-Chloro-2-fluorophenylalanine; (±)-3-Chloro-2-fluorophenylalanine; 2-Fluoro-3-chloro-DL-phenylalanine; 3-Chloro-2-fluoro-DL-α-aminohydrocinnamic acid; (RS)-3-Chloro-2-fluorophenylalanine; Phenylalanine, 3-chloro-2-fluoro-, DL-; 1259993-84-4
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-Dl-Phenylalanine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.