Description

2-Iodo-4-Trifluoromethyl-Benzonitrile is a high-value, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is prized for its unique combination of an electron-withdrawing trifluoromethyl group and a reactive iodine substituent, enabling precise molecular construction. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers due to its ability to modify electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, facilitating carbon-carbon bond formation.
• Fluorine Chemistry: A valuable compound for studying structure-activity relationships (SAR) in fluorinated molecules.

Basic Information

Product Name	2-Iodo-4-Trifluoromethyl-Benzonitrile
CAS No.	1259323-42-6
Molecular Formula	C8H3F3IN
Molecular Weight	297.02 g/mol
Synonyms	4-(Trifluoromethyl)-2-iodobenzonitrile; 2-Iodo-α,α,α-trifluoro-p-tolunitrile; Benzonitrile, 2-iodo-4-(trifluoromethyl)-; 2-Iodo-4-trifluoromethylbenzonitrile; 2-Iodo-4-(trifluoromethyl)benzonitrile; p-Cyanobenzotrifluoride, 2-iodo-; 2-Iodo-α,α,α-trifluoro-4-cyanotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-4-Trifluoromethyl-Benzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets high-purity specifications suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles is provided with each shipment. We support custom synthesis and can tailor specifications to meet specific project requirements, including compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.