Description

8-(Trifluoromethyl)Quinazolin-2-Amine CAS NO 1258652-66-2 is a high-purity, functionalized quinazoline derivative, a critical building block in modern pharmaceutical and agrochemical research. Its core value lies in the trifluoromethyl group, a key pharmacophore known to enhance metabolic stability, lipophilicity, and bioavailability in active molecules. This compound is essential for medicinal chemists and R&D teams in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, where the quinazoline scaffold and fluorine atoms contribute to pesticidal activity and environmental stability.
• Chemical Biology Probe: Employed in the design and synthesis of chemical probes for studying enzyme function and biological target engagement in drug discovery.
• Material Science: Potential building block for creating specialty polymers, liquid crystals, or organic electronic materials due to its rigid, aromatic structure and fluorine content.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	8-(Trifluoromethyl)Quinazolin-2-Amine
CAS No.	1258652-66-2
Molecular Formula	C9H6F3N3
Molecular Weight	213.16 g/mol
Synonyms	2-Amino-8-(trifluoromethyl)quinazoline; 8-(Trifluoromethyl)-2-quinazolinamine; Quinazolin-2-amine, 8-(trifluoromethyl)-; 8-Trifluoromethylquinazolin-2-ylamine; 2-Quinazolinamine, 8-(trifluoromethyl)-; 1258652-66-2; 8-CF3-Quinazolin-2-amine
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl)Quinazolin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.