Description

2H-Quinolizine-3-Carboxylic Acid, Octahydro-2-Oxo-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex, saturated heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing saturated quinolizine cores, which are privileged structures in drug design.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial laboratories for method development and biological screening.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of target molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2H-Quinolizine-3-Carboxylic Acid, Octahydro-2-Oxo-, Ethyl Ester
CAS No.	1258431-03-6
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	Ethyl Octahydro-2-oxo-2H-quinolizine-3-carboxylate; Octahydro-2-oxo-2H-quinolizine-3-carboxylic Acid Ethyl Ester; 2-Oxo-octahydro-2H-quinolizine-3-carboxylic Acid Ethyl Ester; 1258431-03-6; Ethyl 2-oxo-1-azabicyclo[4.3.0]nonane-3-carboxylate (related bicyclic system)
EINECS	Contact for details

Quality Control

Our production of 2H-Quinolizine-3-Carboxylic Acid, Octahydro-2-Oxo-, Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.