Description

(1S)-6,6'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a sophisticated chiral spirobiindane derivative, a key structural motif in advanced asymmetric synthesis. This compound matters as a high-performance ligand precursor or catalyst component, prized for its rigid, well-defined three-dimensional structure which imparts exceptional stereocontrol in chemical transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel synthetic routes to enantiomerically pure compounds.

Application

• Asymmetric Catalysis: Serves as a privileged scaffold for constructing chiral ligands used in transition metal-catalyzed reactions such as hydrogenation, C-C bond formation, and epoxidation.
• Pharmaceutical Intermediate Synthesis: A critical building block or chiral auxiliary in the multi-step synthesis of complex, biologically active molecules requiring high enantiomeric purity.
• Material Science Research: Used in the development of chiral organic frameworks, polymers, or liquid crystals where its rigid spiro structure can induce specific optical or physical properties.
• Agrochemical Development: Employed in the research and synthesis of novel, enantioselective pesticides and herbicides.
• Academic & Industrial R&D: A valuable tool compound for methodological studies in organic chemistry focused on stereoselective synthesis and catalysis.

Basic Information

Product Name	(1S)-6,6'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1258327-01-3
Molecular Formula	C43H24F12O2
Molecular Weight	800.64 g/mol
Synonyms	(S)-6,6'-Bis[3,5-Bis(trifluoromethyl)phenyl]-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol; (1S)-SPINOL Derivative; (S)-SPINPHOS Diol Precursor; Chiral Spiro Diol Ligand; (S)-6,6'-Bis(3,5-bis(trifluoromethyl)phenyl)SPINOL; 1,1'-Spirobiindane-7,7'-diol, 6,6'-bis[3,5-bis(trifluoromethyl)phenyl]-, (1S)-; (S)-TMS-SPINOL Analog
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency critical for catalytic performance. Each lot is characterized by comprehensive analytical methods including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as enantiomeric excess (ee), chemical purity, and residual solvent content to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.