Description

(1S)-2,2',3,3'-Tetrahydro-6,6'-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a sophisticated chiral ligand and catalyst precursor, prized for its sterically demanding and electron-rich structure. This compound is essential for enabling highly selective and efficient asymmetric synthesis in advanced chemical manufacturing. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel, high-value chiral molecules.

Application

• Asymmetric Catalysis: As a key ligand for transition metals (e.g., Rh, Ru, Ir) in enantioselective hydrogenation, hydroformylation, and C-C bond-forming reactions.
• Pharmaceutical Intermediates: Synthesis of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Manufacture of specialty chemicals, flavors, and fragrances where stereochemistry is critical.
• Academic & Industrial Research: A valuable tool for methodology development in organic synthesis and catalysis studies.
• Polymer Catalyst Systems: Component in catalyst systems for stereoregular polymer synthesis.

Basic Information

Product Name	(1S)-2,2',3,3'-Tetrahydro-6,6'-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1258276-31-1
Molecular Formula	C56H70O2
Molecular Weight	775.16 g/mol
Synonyms	(S)-H8-BINOL-DTBP; (S)-2,2',3,3'-Tetrahydro-6,6'-bis(2,4,6-triisopropylphenyl)-1,1'-spirobi[1H-indene]-7,7'-diol; (S)-H8-DTBP-BINOL; (1S)-H8-BINOL-DTBP Ligand; (S)-Octahydro-DTBP-BINOL; DTBP-H8-BINOL (S-form); Chiral Spirobiindanediol Derivative; Asymmetric BINOL-Type Ligand
EINECS	Contact for details

Quality Control

Our production of (1S)-2,2',3,3'-Tetrahydro-6,6'-Bis[2,4,6-Tris(1-Methylethyl)Phenyl]-1,1'-Spirobi[1H-Indene]-7,7'-Diol adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity critical for catalytic performance. All materials are characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.