Description

5-Chloro-2-Hydroxy-3-Iodotoluene is a halogenated phenolic compound that serves as a versatile and valuable synthetic intermediate in advanced organic chemistry. Its unique substitution pattern makes it a critical building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking reliable, high-quality raw materials for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those with halogenated aromatic cores for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the iodine and chlorine substituents contribute to potent biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized monomers for specialty polymers and advanced organic electronic materials.
• Chemical Research & Development: A valuable tool for medicinal and process chemists in lead optimization and route scouting for complex molecule synthesis.
• Dye and Pigment Intermediate: Can be utilized in the production of specialized halogenated dyes and colorants.

Basic Information

Product Name	5-Chloro-2-Hydroxy-3-Iodotoluene
CAS No.	1257535-34-4
Molecular Formula	C7H6ClIO
Molecular Weight	268.48 g/mol
Synonyms	3-Iodo-5-chloro-2-hydroxytoluene; 2-Hydroxy-3-iodo-5-chlorotoluene; 5-Chloro-3-iodo-2-methylphenol; 2-Methyl-5-chloro-3-iodophenol; 1-Chloro-3-iodo-6-methylphenol; Toluene, 5-chloro-2-hydroxy-3-iodo-; 3-Iodo-5-chloro-o-cresol
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Hydroxy-3-Iodotoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.