Description

1-Amino-3-Bromo-4-Fluorobenzene Hydrochloride is a high-purity, halogenated aniline derivative supplied as a hydrochloride salt. This compound is a critical pharmaceutical intermediate and versatile building block for advanced organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries to construct complex molecules for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing halogen-substituted aniline motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromo and fluoro substituents enhance biological activity and stability.
• Material Science Building Block: Serves as a monomer or functionalizing agent in the production of advanced polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Employed as a starting material for synthesizing complex, halogenated dyes and organic pigments.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form biaryl and aryl amine structures.
• Research & Development: Essential for medicinal chemistry programs and academic research focused on structure-activity relationship (SAR) studies and novel heterocycle formation.

Basic Information

Product Name	1-Amino-3-Bromo-4-Fluorobenzene Hydrochloride
CAS No.	1257535-28-6
Molecular Formula	C6H5BrClFN
Molecular Weight	226.47 g/mol
Synonyms	3-Bromo-4-fluoroaniline hydrochloride; 4-Fluoro-3-bromoaniline hydrochloride; 3-Bromo-4-fluorobenzenamine hydrochloride; Benzenamine, 3-bromo-4-fluoro-, hydrochloride (1:1); 1-Amino-3-bromo-4-fluorobenzene HCl; 3-Br-4-F-C6H3-NH2·HCl
EINECS	Contact for details

Quality Control

Our 1-Amino-3-Bromo-4-Fluorobenzene Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and other relevant analytical techniques. Our quality commitment supports applications requiring GMP-grade intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.