Description

6-Amino-2-Bromo-3-Fluorophenol is a high-value, multi-functional halogenated aniline derivative with a unique substitution pattern. This compound is a critical pharmaceutical intermediate and organic synthesis building block, prized for its reactive amine and halogen sites which enable diverse chemical transformations. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its halogenated phenol structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Functional Material Precursor: Employed in the research and production of advanced polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing specialized halogenated dyes and colorants.
• Cross-Coupling Reactions: The bromo and amino groups make it an excellent substrate for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions.

Basic Information

Product Name	6-Amino-2-Bromo-3-Fluorophenol
CAS No.	1257535-00-4
Molecular Formula	C6H5BrFNO
Molecular Weight	206.01 g/mol
Synonyms	2-Bromo-3-fluoro-6-aminophenol; 3-Fluoro-2-bromo-6-hydroxyaniline; 2-Bromo-3-fluoro-6-hydroxyaniline; 6-Hydroxy-2-bromo-3-fluoroaniline; Phenol, 6-amino-2-bromo-3-fluoro-; 6-Amino-2-bromo-3-fluorophenol; 1257535-00-4; 2-Bromo-3-fluoro-6-aminophenol
EINECS	Contact for details

Quality Control

Every batch of 6-Amino-2-Bromo-3-Fluorophenol is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with custom purities up to 99%+ available. Certificates of Analysis (COA) detailing batch-specific results for assay, related substances, residual solvents, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.