Description

8-Boc-2,2-Dioxo-1,3-Dioxa-2-Thia-8-Azaspiro[4.5]Decane is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with enhanced biological activity and drug-like properties. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the fields of central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and new chemical entities (NCEs).
• Protease Inhibitor Development: The spirocyclic scaffold is valuable for constructing molecules that target specific protease enzymes.
• Peptidomimetic Chemistry: Used to create stable, non-peptide mimics of biologically active peptides for enhanced metabolic stability.
• Chemical Biology Research: Serves as a versatile scaffold for constructing molecular probes and tool compounds to study biological pathways.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support route optimization and cGMP manufacturing campaigns.
• Academic & Industrial R&D: Employed in discovery chemistry for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	8-Boc-2,2-Dioxo-1,3-Dioxa-2-Thia-8-Azaspiro[4.5]Decane
CAS No.	1257300-52-9
Molecular Formula	C11H17NO6S
Molecular Weight	291.32 g/mol
Synonyms	8-(tert-Butoxycarbonyl)-2,2-dioxo-1,3-dioxa-2λ6-thia-8-azaspiro[4.5]decane; tert-Butyl 2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate; 8-Boc-1,3-dioxa-2-thia-8-azaspiro[4.5]decane 2,2-dioxide; Boc-protected cyclic sulfamidate; Spirocyclic sulfamidate Boc derivative
EINECS	Contact for details

Quality Control

Our 8-Boc-2,2-Dioxo-1,3-Dioxa-2-Thia-8-Azaspiro[4.5]Decane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports applications from early-stage research through to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.