Description

4-Chloro-7-(Methylsulfonyl)Quinazoline is a high-purity, advanced pharmaceutical intermediate characterized by its distinct quinazoline core functionalized with chloro and methylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Serves as a reactive substrate for further functionalization via nucleophilic aromatic substitution and cross-coupling reactions.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• API Development: Utilized in the research and development stages of active pharmaceutical ingredient (API) manufacturing processes.

Basic Information

Product Name	4-Chloro-7-(Methylsulfonyl)Quinazoline
CAS No.	1256955-28-8
Molecular Formula	C9H7ClN2O2S
Molecular Weight	242.68 g/mol
Synonyms	4-Chloro-7-methanesulfonylquinazoline; 7-(Methylsulfonyl)-4-chloroquinazoline; 4-Chloro-7-methylsulfonylquinazoline; Quinazoline, 4-chloro-7-(methylsulfonyl)-; 1256955-28-8; 4-Chloro-7-(methylsulfonyl)quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(Methylsulfonyl)Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all specification results. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.