Description

1-Naphthalenecarboxamide, n-(2-Aminophenyl)-6-[(7-Methoxy-4-Quinolinyl)Oxy]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted kinase inhibitors and other specialized active pharmaceutical ingredients (APIs).
• Oncology Research: Serves as a core scaffold for developing novel anti-cancer compounds in preclinical and clinical research stages.
• Chemical Biology: Used as a probe or building block in studying protein-ligand interactions and signal transduction pathways.
• Process Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of complex molecules.

Basic Information

Product Name	1-Naphthalenecarboxamide, n-(2-Aminophenyl)-6-[(7-Methoxy-4-Quinolinyl)Oxy]-
CAS No.	1256349-48-0
Molecular Formula	C27H21N3O3
Molecular Weight	435.48 g/mol
Synonyms	N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide; 6-[(7-Methoxy-4-quinolinyl)oxy]-N-(2-aminophenyl)-1-naphthamide; 1256349-48-0; Quinoline-naphthalene amide derivative; Advanced kinase inhibitor intermediate; N-(2-Aminophenyl)-6-(7-methoxyquinolin-4-yloxy)naphthalene-1-carboxamide
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development purposes. Quality is assured through comprehensive analytical testing including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing specific results for each batch is provided. We support development with material suitable for use under GMP guidelines for non-clinical and early-phase clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.