Description

1-(5-Bromopyridin-3-Yl)Cyclopropanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane-carboxylic acid scaffold linked to a brominated pyridine ring. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel crop protection agents and pesticides.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal-organic catalysis and coordination chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1-(5-Bromopyridin-3-Yl)Cyclopropanecarboxylic Acid
CAS No.	1255871-41-0
Molecular Formula	C9H8BrNO2
Molecular Weight	242.07 g/mol
Synonyms	1-(5-Bromo-3-pyridinyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 1-(5-bromo-3-pyridinyl)-; 3-(1-Carboxycyclopropyl)-5-bromopyridine; 5-Bromo-3-cyclopropanecarbonylpyridine; 1-(5-Bromopyridin-3-yl)cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(5-Bromopyridin-3-Yl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.