Description

8-(Boc)-2,8-Diazaspiro[4.5]Decane-3-Carboxylic Acid is a high-purity, protected heterocyclic building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel drug candidates, particularly in the areas of central nervous system (CNS) and metabolic disease therapeutics. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to construct complex molecular architectures with high stereochemical control.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of spirocyclic scaffolds present in various bioactive molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) for new therapeutic targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its rigid spirocyclic structure and functional handles.
• Peptidomimetic Synthesis: Incorporated into peptide backbones to enhance metabolic stability, bioavailability, and conformational rigidity.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche fine chemicals.

Basic Information

Product Name	8-(Boc)-2,8-Diazaspiro[4.5]Decane-3-Carboxylic Acid
CAS No.	1255666-26-2
Molecular Formula	C14H24N2O4
Molecular Weight	284.35 g/mol
Synonyms	tert-Butyl 3-carboxy-2,8-diazaspiro[4.5]decane-8-carboxylate; 2,8-Diazaspiro[4.5]decane-3-carboxylic acid, 8-(1,1-dimethylethyl) ester; 8-Boc-2,8-diazaspiro[4.5]decane-3-carboxylic acid; Boc-protected diazaspirodecane carboxylic acid; 8-(tert-Butoxycarbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid; 1255666-26-2; 8-Boc-2,8-diazaspiro[4.5]decane-3-carboxylate
EINECS	Contact for details

Quality Control

Our 8-(Boc)-2,8-Diazaspiro[4.5]Decane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, supporting its use in regulated research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.