Description

Ethyl 4-Hydroxy-1-(2-Methoxyethyl)-7-Methyl-2-Oxo-1,2-Dihydro-1,8-Naphthyridine-3-Carboxylate is a high-purity, synthetic organic compound belonging to the 1,8-naphthyridine class, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. This product is essential for pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development and production of novel drug candidates.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Antiviral Drug Research: Potential precursor in the development of antiviral agents, leveraging the 1,8-naphthyridine scaffold's biological activity.
• Oncology Therapeutics: Utilized in research programs focused on creating kinase inhibitors and other targeted cancer therapies.
• Chemical Biology & Proteomics: Serves as a core structure for designing chemical probes to study enzyme function and protein interactions.
• Custom Synthesis & Scale-Up: Supplied to CROs and CMOs for process development, optimization, and commercial-scale GMP manufacturing.
• Academic Research: Used in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	Ethyl 4-Hydroxy-1-(2-Methoxyethyl)-7-Methyl-2-Oxo-1,2-Dihydro-1,8-Naphthyridine-3-Carboxylate
CAS No.	1253791-96-6
Molecular Formula	C15H18N2O5
Molecular Weight	306.32 g/mol
Synonyms	Ethyl 4-hydroxy-1-(2-methoxyethyl)-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate; 1,8-Naphthyridine-3-carboxylic acid, 1,2-dihydro-4-hydroxy-1-(2-methoxyethyl)-7-methyl-2-oxo-, ethyl ester; 1253791-96-6; 1-(2-Methoxyethyl)-7-methyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid ethyl ester; 3-Carbethoxy-4-hydroxy-1-(2-methoxyethyl)-7-methyl-1,8-naphthyridin-2(1H)-one; A potential intermediate for SHP2 inhibitors.
EINECS	Contact for details

Quality Control

Our Ethyl 4-Hydroxy-1-(2-Methoxyethyl)-7-Methyl-2-Oxo-1,2-Dihydro-1,8-Naphthyridine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets exacting standards for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.