Description

n-Fmoc-3-Methylamino Propylamine HCl is a protected amine derivative, specifically an Fmoc-protected diamine building block, essential for advanced organic synthesis. This compound is critical for the controlled introduction of a methylamino propylamine spacer into complex molecular architectures, offering precise functionalization. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs), peptide conjugates, and sophisticated linker systems.

Application

• Peptide Synthesis: A key intermediate for introducing a functionalized alkylamine side chain in solid-phase and solution-phase peptide synthesis.
• Linker Chemistry: Serves as a versatile building block for constructing cleavable or non-cleavable linkers in antibody-drug conjugates (ADCs) and other bioconjugates.
• Pharmaceutical Intermediates: Used in the research and development of small molecule drugs, particularly those requiring a tailored amine-containing spacer.
• Protecting Group Strategy: The Fmoc group allows for orthogonal deprotection, making it valuable in multi-step synthetic routes common in medicinal chemistry.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological interactions.
• Material Science: Potential use in the surface functionalization of polymers and nanomaterials to introduce amine-reactive sites.

Basic Information

Product Name	n-Fmoc-3-Methylamino Propylamine HCl
CAS No.	1253582-19-2
Molecular Formula	C₂₀H₂₅ClN₂O₂
Molecular Weight	360.88 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-methylpropane-1,3-diamine hydrochloride; 3-[(Fmoc-methylamino)propylamine] hydrochloride; 1,3-Propanediamine, N1-[(9H-fluoren-9-ylmethoxy)carbonyl]-N3-methyl-, hydrochloride; Fmoc-N-methyl-1,3-diaminopropane HCl; N-Fmoc-N'-methyl-1,3-propanediamine hydrochloride; N-(Fmoc)-N'-methyl-1,3-diaminopropane hydrochloride; Nα-Fmoc-Nω-methyl-1,3-diaminopropane hydrochloride
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Methylamino Propylamine HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.