Description

Methyl 2-(Aminooxy)-2-Methylpropanoate Hydrochloride is a specialized organic salt primarily used as a key synthetic intermediate in pharmaceutical and agrochemical research. Its value lies in the unique aminooxy functional group, which serves as a versatile handle for conjugation, oxime formation, and the synthesis of heterocyclic compounds. This high-purity building block is essential for medicinal chemists and process development scientists working on novel active ingredients, particularly in the development of protease inhibitors, linker molecules for antibody-drug conjugates (ADCs), and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, especially protease inhibitors and targeted therapies.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used in the construction of cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Bioconjugation & Protein Labeling: The aminooxy group facilitates stable oxime ligation with ketone or aldehyde-modified biomolecules.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent for creating smart polymers with responsive properties.
• Chemical Biology Probes: Enables the synthesis of activity-based probes and tools for studying enzyme function and metabolic pathways.

Basic Information

Product Name	Methyl 2-(Aminooxy)-2-Methylpropanoate Hydrochloride
CAS No.	1252016-17-3
Molecular Formula	C5H12ClNO3
Molecular Weight	169.61 g/mol
Synonyms	2-(Aminooxy)-2-methylpropanoic acid methyl ester hydrochloride; Methyl 2-(aminooxy)-2-methylpropionate hydrochloride; O-Methyl 2-(aminooxy)isobutyrate hydrochloride; 2-Methyl-2-[(aminooxy)methyl]propanoate hydrochloride; Aminooxyisobutyric acid methyl ester HCl; Methyl O-aminooxyisobutyrate hydrochloride; Methyl 2-aminooxy-2-methylpropanoate HCl
EINECS	Contact for details

Quality Control

Our Methyl 2-(Aminooxy)-2-Methylpropanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.